Protective efficacy of alpha lipoic acid on acetylcholinesterase activity in aged rat brain regions
P. Arivazhagan
Department of Pediatrics, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB T6E 2S2, Canada
The purpose of the present investigation was to measure the activity of
acetylcholiesterase in discrete regions of young and aged rat brain
before and after DL-a-lipoic acid supplementation. Two groups of male
albino rats were used in this study (4 and 24 months of age).
DL-a-lipoic acid was administered intraperitoneally with a regimen of
100 mg/kg body weight/day using alkaline saline as a vehicle for 7 and
14 days. The activity was measured in the cerebral cortex, cerebellum,
striatum, hippocampus, and hypothalamus, and found to be significantly
decreased in some of the brain regions in aged rats. Administration of
lipoic acid into aged rats reversed the decrease in the activity in the
discrete brain regions. Our results suggest that lipoic acid is
effective in restoration of the activity of acetylcholiesterase in aged
rats.
Key words:
Lipoic acid, ageing, brain and acetylcholinesterase
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