| Thursday 6th September |
| 11:00-13:30: Registration |
| 13:30 | Aubrey de Grey
Cambridge, UK |
Welcome and introductory remarks |
| Session 1: Emerging pharmaceutical interventions in aging (Chair: Arne Akbar) |
| 13:35 | Patrizia D'Alessio
Paris, France |
AISA ("Anti-Inflammatory Senescence Actives") 5203-L molecule to promote healthy aging and prolongation of lifespan
|
| 14:05 | Laura Dugan
La Jolla, USA |
Fullerene-based nanotechnology: developing strategies to study and treat oxidative stress in aging
|
| 14:35 | Randy Strong
San Antonio, USA |
The National Institutes on Aging Interventions Testing Program
|
| 15:05 | Pierre Moreau
Montreal, Canada |
Can we influence the "normal" aging of arteries?
|
| 15:35 | Steve Coles
Los Angeles, USA |
Secrets of the oldest old
|
| 15:50 | Coffee |
| Session 2: Immunotherapy against cancer (Chair: Patrizia d'Alessio) |
| 16:10 | Zheng Cui
Winston-Salem, USA |
From a newly discovered innate anticancer immune response in mice to a new treatment for human cancers
|
| 16:40 | Robert Hawkins
Manchester, UK |
Engineering anti-cancer T cells
|
| 17:10 | Claudia Gravekamp
San Francisco, USA |
Efficacy of cancer vaccines to prevent cancer in the elderly
|
| 17:40 | Coffee |
| Session 3: Persistent viruses in aging and Alzheimer's disease (Chair: Claudia Gravekamp) |
| 18:00 | Ruth Itzhaki
Manchester, UK |
Herpes simplex virus type 1 in brain is a cause of the neuropathological features of Alzheimer's disease
|
| 18:30 | Edward Mocarski
Atlanta, USA |
Virus modulation of cell death pathways
|
| 19:00 | Rita Effros
Los Angeles, USA |
Telomerase-based approaches to enhance immunity to viruses during aging
|
| 19:30 | Arne Akbar
London, UK |
Retarding immune senescence and reducing infections in
ageing
|
| 20:00 | Dinner |
| 21:00 | Welcome reception and Poster session 1 |
| Friday 7th September |
| 7:30 | Breakfast |
| Session 4: Combating neurodegeneration (Chair: Pedro Alvarez) |
| 8:30 | Elizabeth Corder
Durham, USA |
Inherited susceptibility for Alzheimer's disease and estimation of risk for individuals
|
| 9:00 | Jason Emsley (Macklis lab)
Cambridge, USA |
Stimulating neurogenesis in "non-neurogenic" brain regions
|
| 9:30 | Rutledge Ellis-Behnke
Cambridge, USA |
Using nanotchnology to repair the body
|
| 10:00 | Cynthia Lemere
Cambridge, USA |
Cerebral amyloid-beta protein accumulation with aging in cotton-top tamarins: a model of early Alzheimer's disease?
|
| 10:30 | Coffee |
| Session 5: Damage to long-lived intracellular molecules (Chair: Cynthia Lemere) |
| 10:50 | Sataro Goto
Chiba, Japan |
Carbonylation and other modifications of histones: possible roles of epigenetics in aging
|
| 11:20 | Kim Janda
La Jolla, USA |
Immunopharmacotherapy against weight gain
|
| 11:50 | Paola Scaffidi
Bethesda, USA |
Nuclear architecture: building bulwarks against aging
|
| 12:20 | Pedro Alvarez
Houston, USA |
Microbial degradation of 7-ketocholesterol
|
| 12:50 | Lunch |
| Session 6: short talks selected from submitted abstracts (Chairs: Giuseppina Colonna-Romano and Vadim Fraifeld) |
| 13:50 | Giuseppina Colonna-Romano
Palermo, Italy |
B cell immunosenescence in the elderly |
| 14:05 | Christian Dumpitak
Duesseldorf, Germany |
Accelerated protein aggregation and amyloid fibril formation of the prion protein in the presence of glycogen |
| 14:20 | John Schloendorn
Tempe, USA |
Medical bioremediation |
| 14:35 | Anund Hallen
Uppsala, Sweden |
Accumulating insoluble protein and rate of aging |
| 14:50 | Andrew Hessel
Edmonton, Canada |
Synthetic viruses targeting cancer
|
| 15:05 | Vadim Fraifeld
Beer-Sheva, Israel |
Do mitochondrial DNA and metabolic rate complement each other in determination of the mammalian maximal life span? |
| 15:20 | Coffee |
| Session 7: New directions in gene therapy (Chair: Marisol Corral-Debrinski) |
| 15:40 | Nicola Philpott
London, UK |
Non-integrating lentiviral vectors for stable and efficient gene delivery to post-mitotic tissue
|
| 16:10 | Michele Calos
Palo Alto, USA |
Adding beneficial genes to the body with phage integrases
|
| 16:40 | Michael Holmes
Richmond, USA |
High efficiency human genome editing using designed zinc finger nucleases
|
| 17:10 | Coffee |
| Session 8: Rescue of mitochondrial mutations (Chair: Michele Calos) |
| 17:30 | Volkmar Weissig
Boston, USA |
Manipulating (rejuvenating?) the mitochondrial genome
|
| 18:00 | Dimitra Kyriakouli
Newcastle upon Tyne, UK |
Mutations of the mitochondrial genome: treatment |
| 18:15 | Ian Holt
Cambridge, UK |
Allotopic expression: mitochondrial to nuclear gene transfer
|
| 18:45 | Marisol Corral-Debrinski
Paris, France |
Allotopic mRNA localization to the mitochondrial surface: a tool for rescuing respiration deficiencies
| 19:15 | Tonio Enriquez
Zaragoza, Spain |
Inteins and allotopic expression of mtDNA encoded proteins |
|
| 19:30 | Samit Adhya
Calcutta, India |
Use of a parasite-derived protein complex to modulate the function of mitochondria in human cells
|
| 20:00 | Dinner |
| 21:00 | Poster session 2 |
| Saturday 8th September |
| 7:30 | Breakfast |
| Session 9: New approaches to eliminating beta-amyloid (Chair: Jan Vijg) |
| 8:30 | Ashley Bush
Cambridge, USA |
Zinc, copper and amyloid in Alzheimer's disease
|
| 9:00 | Beka Solomon
Tel Aviv, Israel |
Immunological approaches for amyloid beta clearance toward Alzheimer's disease treatment
|
| 9:30 | Yoh Matsumoto
Tokyo, Japan |
Non-viral Abeta DNA vaccine therapy against Alzheimer disease - safety, long-term effects and mechanisms of Abeta reduction
|
| 10:00 | David Morgan
Tampa, USA |
Gene therapy with amyloid degrading proteases in mouse models of amyloid deposition
|
| 10:30 | Coffee |
| Session 10: Non-specific nuclear DNA damage in aging (Chair: David Morgan) |
| 10:50 | Jan Vijg
Novato, USA |
Age-related stochastic dysfunction of the genome: a natural limit to life span?
|
| 11:20 | Michael Siciliano
Houston, USA |
Microsatellite instability increases with age in normal individuals as well in patients with inherited mismatch repair mutations
|
| 11:50 | Aubrey de Grey
Cambridge, UK |
Might the biogerontological impact of non-specific nDNA damage be slight?
|
| 12:20 | Lunch |
| SENS Lecture (Chair: Aubrey de Grey) |
| 13:20 | Chris Phoenix
Brooklyn, USA |
Getting ahead of aging |
| Session 11: short talks selected from submitted abstracts (Chair: Aubrey de Grey) |
| 14:05 | Natasha Vita-More
Austin, USA |
Brave biological design -- how biotechnology, generative media, and other currents are changing creative inquiry in the arts & sciences |
| 14:20 | Anders Sandberg
Oxford, UK |
When Nature isn't wise: evolutionary medicine and human enhancement |
| 14:35 | Steven Horrobin
Edinburgh, UK |
The value of life to persons as conative processes |
| 14:50 | Coffee |
| Session 12: Engineering regeneration of complex structures (Chair: Miodrag Stojkovic) |
| 15:10 | David Steenblock
Mission Viejo, USA |
Bone marrow stem cell therapy: a major breakthrough for chronic diseases and anti-aging |
| 15:25 | James Larrick
Mountain View, USA |
Specific targeting of therapeutic stem cells for cardiovascular disease |
| 15:40 | Amit Patel
Pittsburgh, USA |
Scar: is rejuvenation possible? |
| 16:10 | Stephen Minger
London, UK |
Therapeutic applications of human stem cells - prospects and challenges
|
| 16:40 | Chris Mason
London, UK |
Regenerative Medicine 2.0
|
| 17:10 | David Gardiner
Irvine, USA |
Engineering a blastema: steps toward regenerating a limb
|
| 17:40 | Coffee |
| Session 13: Deriving autologous embryonic stem cells (Chair: Chris Mason) |
| 18:00 | Chang-Kyu Lee
Seoul, Korea |
Interspecies somatic cell nuclear transfer for establishing embryonic stem cells with desired genotype
|
| 18:30 | Wolfgang Engel
Gottingen, Germany |
From stem cells to male germ cells
|
| 19:00 | Miodrag Stojkovic
Valencia, Spain |
Timeless human embryonic stem cells
|
| 19:30 | Marius Wernig (Jaenisch lab)
Cambridge, USA |
Direct reprogramming of somatic cells into pluripotent stem cells
|
| 20:00 | Dinner |
| 21:00 | Poster session 3 |
| Sunday 9th September |
| 7:30 | Breakfast |
| Session 14: Telomeres and cell senescence (Chair: Mike Conboy) |
| 8:30 | Mary Perry
Frederick, USA |
The p53 inhibitory protein Mdm2 does not prevent aging
|
| 9:00 | Gillian Butler-Browne
Paris, France |
Identification of biomarkers of human muscle aging and senescence
|
| 9:30 | Lenhard Rudolph
Hannover, Germany |
Telomere dysfunction induces cell intrinsic checkpoints and environmental alterations limiting stem cell function
|
| 10:00 | Walter Berger
Wien, Austria |
ALTernative ways to immortality. blessing or curse?
|
| 10:30 | Coffee
|
| Session 15: Maintenance of extracellular material and milieu (Chair: Gillian Butler-Browne) |
| 10:50 | Julia Rist (Franklin lab)
Cambridge, UK |
Ageing and myelin repair in the CNS
|
| 11:20 | Mike Conboy
Berkeley, USA |
Stem cells dividing, sister chromatids choose fate: old stays, young moves on
|
| 11:50 | Cato Laurencin
Charlottesville, USA |
Musculoskeletal regenerative engineering: taking on the grand challenges
|
| 12:20 | Lunch |
| Session 16: short talks selected from submitted abstracts (Chairs: Matthew O'Connor and David Melzer) |
| 13:20 | Calogero Caruso
Palermo, Italy |
Genetics of successful ageing: goals and future perspectives, a pharmacogenomics approach to prevent unsuccessful ageing |
| 13:35 | David Melzer
Exeter, UK |
Genetic polymorphisms and human ageing: lessons for SENS |
| 13:50 | Andrew Mayes
Sharnbrook, UK |
Repetitive mild heat shock as a mechanism to delay ageing in human dermal fibroblasts |
| 14:05 | Eugenio Mocchegiani
Ancona, Italy |
Zinc, metallothioneins and longevity: effect of zinc supplementation. ZINCAGE study |
| 14:20 | Dawn Mazzatti
Sharnbrook, UK |
Age-dependent effects of zinc on gene expression and zinc status in peripheral blood mononuclear cells |
| 14:35 | Alexander Michalow
Bourbonnais, USA |
Searching for the fountain of youth: novel caloric restriction mimetics |
| 14:50 | Oren Froy
Rehovot, Israel |
The relationship between calorie restriction and the biological clock: lessons from long-lived transgenic mice |
| 15:05 | Mikhail Shchepinov
Oxford, UK |
Isotope effect and enhanced longevity |
| 15:20 | Sergiy Volovyk
Durham, USA |
Radiation effects as molecular patterns for aging phenomena and human pathophysiology |
| 15:35 | Matthew O'Connor
Berkeley, USA |
Stem cells endogenous to aged skeletal muscle retain high telomerase activity |
| 15:50 | Coffee |
| Session 17: Long-term goals for biomedical gerontology (Chair: Michael Rose) |
| 16:10 | Ben Best
Detroit, USA |
Evidence that cryonics may work
|
| 16:40 | Ray Kurzweil
Boston, USA |
Accelerating change |
| 17:40 | Coffee |
| Session 18: Outreach to key stakeholder communities (Chair: Aubrey de Grey) |
| 18:00 | Linda Powers
Bethesda, USA |
Pots of gold in anti-aging regenerative medicine? |
| 18:30 | Michael Rose
Irvine, USA |
Slowing and then stopping aging
|
| 19:00 | Huber Warner
Minneapolis, USA |
Making the political case for biogerontology funding: a view from the trenches
|
| 19:30 | Bernard Siegel
Wellington, USA |
The inevitable legal battle over Engineered Negligible Senescence
|
| 20:00 | Gala Dinner |
| Monday 10th September |
| 8:00 | Breakfast |
| 9:30 | Punting on the Cam |
| 11:30 | C O N F E R E N C E A D J O U R N S |
| Thank you for your attendance and participation! |